Amphotericin B For Injection I.P. is a freeze dried preparation of Amphotericin B for intravenous injection. It should be administered primarily to patients with progressive, potentially life-threatening fungal infections. Amphotericin B For Injection I.P. should not be administered to treat non-invasive fungal infections such as oral thrush, vaginal candidiasis and oesophageal candidiasis in patients having normal neutrophil counts. It is specifically indicated in the treatment of fungal infections susceptible to Amphotericin B such as the one caused by Candida spp., Aspergillus spp., Crytococcus neoformans, Mucor spp., Rhodotorula spp., Absidia spp., Blastomyces dermatitidis.
It comes in two types liposomal & non-liposomal where the latter is cheaper. It is manufactured in India by many brands like Bharat Serum, Intas, Dabur etc.
The usual daily maintenance dose of Amphotericin B For Injection I.P. is equivalent to 0.5 to 1mg/kg of Amphotericin B. At any given time of administration, a total dose of 1.5mg/kg should never be exceeded.
Body as a whole: fever (sometimes accompanied by shaking chills usually occurring within 15 to 20 minutes after initiation of treatment); malaise; weight loss.
Cardiopulmonary: hypotension; tachypnea.
Gastrointestinal: anorexia; nausea; vomiting; diarrhea; dyspepsia; cramping epigastric pain.
Hematologic: normochromic, normocytic anemia.
Local: pain at the injection site with or without phlebitis or thrombophlebitis.
Musculoskeletal: generalized pain, including muscle and joint pains.
Renal: decreased renal function and renal function abnormalities including: azotemia, hypokalemia, hyposthenuria, renal tubular acidosis; and nephrocalcinosis. These usually improve with interruption of therapy. However, some permanent impairment often occurs, especially in those patients receiving large amounts (over 5 g) of Amphotericin B or receiving other nephrotoxic agents. In some patients hydration and sodium repletion prior to Amphotericin B administration may reduce the risk of developing nephrotoxicity. Supplemental alkali medication may decrease renal tubular acidosis.
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