Aprepitant, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy, including high-dose cisplatin.
Aprepitant is for the treatment of adult patients with chemotherapy induced nausea and vomiting.
Aprepitant is given for 3 days as part of a regimen that includes a corticosteroid and a 5-HT3 antagonist. The recommended dose of Aprepitant is 125 mg orally 1 hour prior to chemotherapy treatment (Day 1) and 80 mg once daily in the morning on Days 2 and 3.
Call your doctor at once if you have a serious side effect such as:
- feeling like you might pass out;
- feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin; or
- fever, chills, body aches, flu symptoms, sores in your mouth and throat.
Less serious side effects may include:
- nausea, vomiting, heartburn.
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