Bivalirudin  is a specific and reversible direct thrombin inhibitor (DTI). It is a synthetic congener of the naturally occurring drug hirudin (found in the saliva of the medicinal leech Hirudo medicinalis).Bivalirudin is a DTI that overcomes many limitations seen with indirect thrombin inhibitors, such as heparin. Bivalirudin is a short, synthetic peptide that is potent, highly specific, and a reversible inhibitor of thrombin.It inhibits both circulating and clot-bound thrombin.It does not require a binding cofactor such as antithrombin and does not activate platelets. These characteristics make bivalirudin an ideal alternative to heparin.

Additional Information

Bivalirudin is intended for IV use only and is supplied as a sterile, lyophilized product in single-use, glass vials. After reconstitution, each vial delivers 250 mg of bivalirudin.

Side Effects

Very common: More than 1 in 10 people who have Bivalirudin

  • minor bleeding from various sites of the body

Common: More than 1 in 100 people who have Bivalirudin

  • abnormal laboratory test results
  • bruising
  • injection site problems such as bleeding, pain, discomfort or collection of blood under the skin
  • major bleeding from various sites of the body – certain types of bleeding may be fatal. Seek medical advice if you develop any unusual bleeding
  • thrombosis – this may be fatal

Uncommon: More than 1 in 1000 people who have Bivalirudin

  • blood and bone marrow problems
  • blood in the urine
  • collection of blood under the skin
  • coughing blood
  • headaches
  • hypersensitivity reactions such as tightness of chest, wheezing, anaphylaxis or anaphylactic shock. Anaphylaxis or anaphylactic shock may be fatal
  • lowered blood pressure
  • melaena
  • nausea
  • nose bleed
  • vomiting blood

Rare: More than 1 in 10,000 people who have Bivalirudin

  • back pain
  • breathing difficulties
  • chest pain
  • circulation problems
  • fistula
  • groin pain
  • irregular heart rate
  • other heart problems or a heart attack
  • skin rash or rashes
  • urticaria
  • vomiting

Very rare: Fewer than 1 in 10,000 people who have Bivalirudin

  • compartment syndrome

Pack Size

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