Pamidronate Disodium IV Infusion BP 30 mg & 60 mg

Pamidronate Disodium  IV Infusion BP 30 mg & 60 mg is used in  treatment of moderate to severe hypercalcemia associated with malignancy with or without bone metastases; treatment of moderate to severe Paget disease of bone; treatment of osteolytic bone lesions of multiple myeloma and bone metastases of breast cancer in conjunction with standard chemotherapy.

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Moderate to Severe Hypercalcemia of Malignancy
Adults

IV For moderate, give 60 to 90 mg as an initial single-dose infusion over 2 to 24 h. For severe, give 90 mg as an initial single-dose infusion over 2 to 24 h. For retreatment, same as initial therapy, at least 7 days after initial dose.

Paget Disease
Adults

IV 30 mg/day as a 4-h infusion on 3 consecutive days for a total dose of 90 mg. For retreatment, same as initial therapy, when clinically indicated.

Osteolytic Bone Metastases of Breast Cancer
Adults

IV 90 mg as a 2-h infusion every 3 to 4 wk.

Osteolytic Bone Lesions of Multiple Myeloma
Adults

IV 90 mg as a 4-h infusion on a monthly basis.

Cardiovascular

Atrial fibrillation; atrial flutter; cardiac failure; hypertension; syncope; tachycardia.

CNS

Asthenia; anxiety; fatigue; headache; insomnia; paresthesia; psychosis; somnolence.

Dermatologic

Sweating.

Endocrine

Hypothyroidism.

GI

Abdominal pain; anorexia; constipation; diarrhea; dyspepsia; GI hemorrhage; nausea; stomatitis; vomiting.

Genitourinary

UTI; uremia; renal toxicity.

Hematologic-Lymphatic

Anemia; granulocytopenia; leukopenia; neutropenia; thrombocytopenia.

Lab Tests

Hypocalcemia; hypokalemia; hypomagnesemia; hypophosphatemia.

Local

Infusion-site reaction.

Musculoskeletal

Arthralgia; arthrosis; back pain; bone pain; musculoskeletal pain; myalgia; osteonecrosis primarily of the jaws.

Respiratory

Coughing; dyspnea; pleural effusion; rales; rhinitis; sinusitis; upper respiratory infection.

Miscellaneous

Edema; fever; metastases; moniliasis; pain; allergic manifestations (eg, hypotension, dyspnea, angioedema, anaphylactic shock) .