Vancomycin Hydrochloride Injection 500 / 1000 mg

Vancomycin Hydrochloride Injection 500 & 1000 mg  is a tricyclic glycopeptide antibiotic derived from Amycolatopsis orientalis .Vancomycin is indicated for the treatment of serious or severe infections caused by susceptible strains of methicillin-resistant (beta-lactam-resistant) staphylococci. It is indicated for penicillin-allergic patients, for patients who cannot receive or who have failed to respond to other drugs, including the penicillins or cephalosporins .Vancomycin is indicated for initial therapy when methicillinresistant staphylococci are suspected, but after susceptibility data are available, therapy should be adjusted accordingly.Vancomycin is effective in the treatment of staphylococcal endocarditis. Its effectiveness has been documented in other infections due to staphylococci, including septicemia ,bone infections, lower respiratory tract infections, skin and skin structure infections. When staphylococcal infections are localized and purulent, antibiotics are used as adjuncts to appropriate surgical measures.

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Rapid bolus administration (e.g., over several minutes) may be associated with exaggerated hypotension, including shock, and, rarely,cardiac arrest. Vancomycin should be administered over a period of not less than 60 minutes to avoid rapid-infusion-related reactions. Stopping the infusion usually results in prompt cessation of these reactions.

Infusion-Related Events

During or soon after rapid infusion of vancomycin, patients may develop anaphylactoid reactions, including hypotension, wheezing, dyspnea, urticaria. Rapid infusion may also cause flushing of the upper body

Nephrotoxicity

Renal failure, principally manifested by increased serum creatinine or BUN concentrations, especially in patients administered large doses of vancomycin, has been reported rarely.

Gastrointestinal

Onset of pseudomembranous colitis symptoms may occur during or after antibiotic treatment .

Ototoxicity

A few dozen cases of hearing loss associated with vancomycin have been reported. Most of these patients had kidney dysfunction or a preexisting hearing loss or were receiving concomitant treatment with an ototoxic drug.

Phlebitis

Inflammation at the injection site has been reported.