Yondelis (also known as ecteinascidin 743 or ET-743, Trabectedin) is an anti-tumor drug used in the treatment of adult patients with advanced soft tissue sarcoma, after failure of anthracyclines and ifosfamide, or who are unsuited to receive these agents. Efficacy data are based  mainly on liposarcoma and leiomyosarcoma patients.  Yondelis in combination with pegylated liposomal doxorubicin (PLD) is indicated for the treatment of  patients with relapsed platinum-sensitive ovarian cancer.  It is manufactured by Zeltia and Johnson and Johnson under the brand name Yondelis.

Brand Name: Yondelis 1mg
Contents: Trabectedin
Form: Injection powder
Strength: 0.25mg  & 1mg
Manufactured By:  J & J
Packing: Injection

Manufacturer: Johnson & Johnson Belgium
The European Commission and the U.S. Food and Drug Administration (FDA) have granted orphan drug status to trabectedin for soft tissue sarcomas and ovarian cancer.

Additional Information

Product Details:

Import License No. FF-116-15404 for 1 vial, Inclusive of all taxes Beerse, Belgium
Imported & Marketed in India by 30, Forjett Street, Mumbai 400036

Each Single use vial contains Trabectedin : 1 mg
Reconstituted solution: Reconstitute with 20 ml of sterile water for injection I.P.
After reconstitution, 1 ml of solution
Contains 0.05 mg Trabectedin.
Diluted solution: Refer Instruction for Use and Handling in the package leaflet.

Side Effects


Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect.

Disturbances of the gut, such as nausea and vomiting, constipation, diarrhoea, indigestion, abdominal pain.
Decrease in the numbers of white blood cells (neutropenia), platelets (thrombocytopenia) or red blood cells (anaemia) in the blood.
Fatigue, weakness or loss of strength (asthenia).
Loss of appetite and weight loss.
Elevated levels of liver enzymes.
Injection site reaction.
Problems with the nerves, for example causing changes in sensation such as pins and needles (paraesthesia) or numbness.
Shortness of breath (dyspnoea).
Pain in muscle or joints (myalgia or arthralgia).
Hair loss (alopecia).
Low blood pressure (hypotension).
Swollen ankles (peripheral oedema).
Difficulty sleeping (insomnia).
Inflammation of the lining of the mouth (stomatitis).
Bacterial, viral or fungal infections, sometimes serious.
Muscle breakdown (rhabdomyolysis).

Pack Size

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