Zoldria 4mg

Zoledronic acid is given as an injection into a vein (intravenous, or IV) over 15 minutes or more. The usual dose is 4 milligrams (mg), although the dose may need to be lower in people with kidney problems. The timing will depend on the reason you are getting the drug. When zoledronic acid is used to treat high blood calcium levels it is often given as a one-time dose. To help treat tumors in the bones, it is often given once every 3 to 4 weeks.

You will likely be given IV fluids and/or advised to drink plenty of fluids while getting this drug to keep you hydrated and reduce the chance of kidney damage. Your doctor may also recommend that you take a multi-vitamin (with vitamin D) and a calcium supplement each day.

Your doctor may delay or even stop this drug if your kidney function tests are abnormal.

Fever (lasting a few days after the infusion)*

Flu-like symptoms (fever, chills, flushing, bone and muscle aches) in the first 3 days after your injection, which may last a week or more*

Pain or redness at injection site

Bone or joint pain

Muscle aches

Runny nose

Cough

Nausea/vomiting

Loss of appetite

Constipation

Diarrhea

Shortness of breath

Feeling dizzy or faint

Feeling tired

Urinary tract infection

Anemia (low red blood cell counts) which can cause tiredness, shortness of breath

Blood test results showing the drug may be affecting your kidneys (Your doctor will explain the importance of these findings, if any.)*

Trouble sleeping

Agitation

Low blood calcium levels (could lead to muscle pain, cramps, or spasms; abnormal sensations on the face, hands, or feet; or seizures)*

Damage to bones in jaw*

Broken femur (thigh bone) after little or no injury, starting with groin or thigh pain

Serious allergic reactions*

Kidney failure

Trouble breathing, coughing, tightness in the chest*

Irregular heartbeat (atrial fibrillation)

Bone and/or joint pain severe enough to require the drug be stopped

Eye irritation or redness